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CAS号 | 1990504-72-7 | 货号 | BCP44102 |
关联产品 | 1990504-34-1(Bomedemstat) | ||
中文名 | Bomedemstat ditosylate | ||
英文名 | Bomedemstat ditosylate | ||
中文别名 | |||
英文别名 | IMG-7289 ditosylate; IMG 7289; IMG7289; | ||
SMILES | CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCN(CC1)C(=O)C(CCCNC2CC2C3=CC=C(C=C3)F)NC(=O)C4=CC=C(C=C4)N5C=CN=N5 | ||
化学名称 | |||
分子式 | C42H50FN7O8S2 | 分子量 | 864.02 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Bomedemstat is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndrome, and Myelofibrosis. IMG-7289 selectively inhibited proliferation and induced apoptosis of JAK2 V617F cells by concomitantly increasing expression and methylation of p53, and, independently, the pro-apoptotic factor PUMA and by decreasing the levels of its antiapoptotic antagonist BCLXL. |
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