AZD-7451
| CAS No. | 1079274-94-4 | Cat. No. | BCP44112 |
| Name | AZD-7451 | ||
| Synonyms | AZD7451; AZD 7451; AZ12607092; AZ 12607092; AZ-12607092; | ||
| Formula | C18H19FN8O | M. Wt | 382.39 |
| Description | AZD7451 is a tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity. AZD7451 binds to TRK, thereby preventing the neurotrophin-TRK interaction and subsequent TRK activation. This may eventually result in an inhibition of tumor cell proliferation in TRK-expressing tumor cells. TRK, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth, invasion and survival. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Trk Receptor | ||
Structure
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