AZD-7451 New
Data Sheet
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| CAS No. | 1079274-94-4 | Cat. No. | BCP44112 |
| Name | AZD-7451 | ||
| Synonyms | AZD7451; AZD 7451; AZ12607092; AZ 12607092; AZ-12607092; | ||
| SMILES | CC(C)OC1=NNC(=C1)N2C=NC3=C2N=C(C=C3)NC(C)C4=NC=C(C=N4)F | ||
| Chemical Name | |||
| Formula | C18H19FN8O | M. Wt | 382.39 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AZD7451 is a tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity. AZD7451 binds to TRK, thereby preventing the neurotrophin-TRK interaction and subsequent TRK activation. This may eventually result in an inhibition of tumor cell proliferation in TRK-expressing tumor cells. TRK, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth, invasion and survival. | ||
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