D-DOPA

Description	D-DOPA is the dextrorotary isomer of the dopamine precursor L-DOPA. It can be converted to L-DOPA via sequential oxidation and transamination, which are mediated by D-amino acid oxidase and DOPA transaminase, respectively, in rat kidney homogenates. It reduces the number of dopaminergic neurons in primary rat embryonic mesencephalic cultures in a concentration-dependent manner. Intraventricular administration of D-DOPA increases striatal dopamine levels in rats. D-DOPA induces contralateral turns in a rat model of Parkinson's disease induced by 6-OHDA.
Pathways	Neuro Signaling Pathway GPCR/G Protein
Targets	Dopamine Receptor

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