Anagyrin

Description	Anagyrine is an alkaloid that has been found in L. albus and has nematocidal and anticancer activities. It binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2,096 µM, respectively, in radioligand binding assays using pig brain membranes that endogenously express high levels of the receptors. Anagyrine decreases survival of B. xylophilus worms. It inhibits proliferation of TE-671 and SH-SY5Y cancer cells. Maternal ingestion of anagyrine during gestation is associated with the teratogenic condition crooked calf disease in cattle.
Pathways	Ion Channel/Membrane Transporter Neuro Signaling Pathway
Targets	nAChR

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