AN0128
| CAS号 | 872044-70-7 | 货号 | BCP44562 |
| 中文名 | AN0128 | ||
| 英文名 | AN0128 | ||
| 中文别名 | |||
| 英文别名 | CRM-0005; ONT-0001; AN-0128; CRM0005; ONT0001; AN 0128; CRM 0005; ONT 0001; | ||
| 分子式 | C20H16BCl2NO3 | 分子量 | 400.06 |
| 生物活性 | AN0128 is a tumour necrosis factor alpha (TNF-α) inhibitor potentially for the treatment of atopic dermatitis. AN0128 showed promising combination of anti-bacterial and anti-inflammatory activities. This compound is now in clinical development for dermatological conditions. Daily application of AN0128 (1%) compared with controls reduced bone loss by 38 to 44% (P < 0.05), while vehicle alone had no effect (P > 0.05). The reduction in bone loss with AN0128 was similar to that achieved with a NSAID, ketorolac, and Total toothpaste containing triclosan. AN0128 also reduced the level of gingival inflammation 42% compared with the ligature only (P < 0.05), whereas vehicle alone had no effect (P > 0.05). The results indicate that AN0128 significantly reduces the formation of an inflammatory infiltrate and reduces bone loss, measured histologically and by micro-CT. | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | TNF Receptor | ||
结构式
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