Tovinontrine
| CAS No. | 2062661-53-2 | Cat. No. | BCP44778 |
| Name | Tovinontrine | ||
| Synonyms | IMR-687; IMR 687; IMR687; | ||
| Formula | C21H26N6O2 | M. Wt | 394.47 |
| Description | Tovinontrine, also known as IMR-687, is a phosphodiesterase 9 (PDE9) inhibitor. IMR-687 increased cGMP and HbF in erythroid K562 and UT-7 cells and increased the percentage of HbF positive erythroid cells generated in vitro using a two-phase liquid culture of CD34+ progenitors from sickle cell blood or bone marrow. Oral daily dosing of IMR-687 in the Townes transgenic mouse SCD model, increased HbF and reduced red blood cell sickling, immune cell activation and microvascular stasis. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Phosphodiesterase/PDE | ||
Structure
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