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CAS No. | 2062661-53-2 | Cat. No. | BCP44778 |
Name | Tovinontrine | ||
Synonyms | IMR-687; IMR 687; IMR687; | ||
SMILES | CC1CN(CC1C2=CN3C(=CN=C3C4CCOCC4)C(=O)N2)CC5=NC=CC=N5 | ||
Chemical Name | |||
Formula | C21H26N6O2 | M. Wt | 394.47 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Tovinontrine, also known as IMR-687, is a phosphodiesterase 9 (PDE9) inhibitor. IMR-687 increased cGMP and HbF in erythroid K562 and UT-7 cells and increased the percentage of HbF positive erythroid cells generated in vitro using a two-phase liquid culture of CD34+ progenitors from sickle cell blood or bone marrow. Oral daily dosing of IMR-687 in the Townes transgenic mouse SCD model, increased HbF and reduced red blood cell sickling, immune cell activation and microvascular stasis. |
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