K-975
  • 化学数据
CAS号 2563855-03-6 货号 BCP44951
中文名 K-975
英文名 K-975
中文别名
英文别名 K975; K 975;
分子式 C16H14ClNO2 分子量 287.74
  • 用途
生物活性 K-975 is a first-in-class TEAD inhibitor, directly inhibiting YAP/TAZ-TEAD protein-protein interaction and showing a potent anti-tumor effect in malignant pleural mesothelioma. K-975 was covalently bound to an internal cysteine residue located in the palmitate-binding pocket of TEAD. K-975 had a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD in cell-free and cell-based assays. Furthermore, K-975 potently inhibited the proliferation of NF2-non-expressing MPM cell lines compared with NF2-expressing MPM cell lines. K-975 also suppressed tumor growth and provided significant survival benefit in MPM xenograft models.
信号通路 Wnt/Stem Cell 

结构式

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