ETP-45658
| CAS No. | 1198357-79-7 | Cat. No. | BCP45165 |
| Name | ETP-45658 | ||
| Synonyms | ETP 45658; ETP45658; | ||
| Formula | C16H17N5O2 | M. Wt | 311.34 |
| Description | ETP 45658 is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively). Inhibits proliferation of multiple cancer cell lines in vitro and reduces Akt phosphorylation levels in vivo. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | PI3K | ||
Structure
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