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ETP-45658 Chemical Structure

ETP-45658

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP45165CAS No. ：1198357-79-7Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1198357-79-7 Cat. No. BCP45165
Name ETP-45658
Synonyms ETP 45658; ETP45658;
SMILES CN1C2=C(C=N1)C(=NC(=N2)C3=CC(=CC=C3)O)N4CCOCC4
Chemical Name
Formula C16H17N5O2 M. Wt 311.34
Purity 98% Storage Store at 4-8°C
Description ETP 45658 is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively). Inhibits proliferation of multiple cancer cell lines in vitro and reduces Akt phosphorylation levels in vivo.
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