NVR 3-778
| CAS No. | 1445790-55-5 | Cat. No. | BCP45472 |
| Name | NVR 3-778 | ||
| Synonyms | NVR3 778; NVR-3-778; K-89; K 89; K89; NVR3778; NVR 3778; NVR-3778; | ||
| Formula | C18H16F4N2O4S | M. Wt | 432.39 |
| Description | NVR 3-778 is the first capsid assembly modulator (CAM) that has demonstrated antiviral activity in hepatitis B virus (HBV)-infected patients. NVR 3-778 inhibited the generation of infectious HBV DNA-containing virus particles with a mean antiviral 50% effective concentration (EC50) of 0.40 µM in HepG2.2.15 cells. The antiviral profile of NVR 3-778 indicates pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication. | ||
| Pathways | Microbiology/Virology | ||
| Targets | HBV | ||
Structure
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