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CAS No. | 1445790-55-5 | Cat. No. | BCP45472 |
Name | NVR 3-778 | ||
Synonyms | NVR3 778; NVR-3-778; K-89; K 89; K89; NVR3778; NVR 3778; NVR-3778; | ||
SMILES | C1CN(CCC1O)S(=O)(=O)C2=C(C=CC(=C2)C(=O)NC3=CC(=C(C(=C3)F)F)F)F | ||
Chemical Name | |||
Formula | C18H16F4N2O4S | M. Wt | 432.39 |
Purity | 98% | Storage | Store at 4-8°C |
Description | NVR 3-778 is the first capsid assembly modulator (CAM) that has demonstrated antiviral activity in hepatitis B virus (HBV)-infected patients. NVR 3-778 inhibited the generation of infectious HBV DNA-containing virus particles with a mean antiviral 50% effective concentration (EC50) of 0.40 µM in HepG2.2.15 cells. The antiviral profile of NVR 3-778 indicates pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication. |
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