Bomedemstat
| CAS号 | 1990504-34-1 | 货号 | BCP45548 |
| 中文名 | Bomedemstat | ||
| 英文名 | Bomedemstat | ||
| 中文别名 | |||
| 英文别名 | IMG-7289; IMG 7289; IMG7289; | ||
| 分子式 | C28H34FN7O2 | 分子量 | 519.61 |
| 生物活性 | Bomedemstat is an orally available, irreversible inhibitor of lysine-specific demethylase 1 (LSD1), with potential antineoplastic activity. Upon administration, bomedemstat binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor suppressor genes. In addition, LSD1 demethylates mono- or di-methylated H3K9 which increases gene expression of tumor promoting genes; thus, inhibition of LSD1 also promotes H3K9 methylation and decreases transcription of these genes. Altogether, this may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. LSD1, an enzyme belonging to the flavin adenine dinucleotide (FAD)-dependent amine oxidase family is overexpressed in certain tumor cells and plays a key role in the regulation of gene expression, tumor cell growth and survival. | ||
| 上下游产品 | 1990504-72-7（Bomedemstat ditosylate） | ||
| 信号通路 | Epigenetics | ||
| 靶 点 | Histone Demethylase | ||
结构式
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