VT-103
  • 化学数据
CAS号 2290608-13-6 货号 BCP45566
中文名 VT-103
英文名 VT-103
中文别名
英文别名 VT 103; VT103;
分子式 C18H17F3N4O2S 分子量 410.41
  • 用途
生物活性 VT-103 is a potent and selective TEAD Auto-palmitoylation inhibitor that Inhibits Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT103 is a TEAD1-selective inhibitor. VT103 is an analog of VT101, which has 238 improved potency and good oral pharmacokinetics in mice. VT103 selectively inhibited endogenous TEAD1 palmitoylation in cells. VT103 significantly downregulated the expression of the Hippo pathway target genes, CTGF and CYR61, in the NF2-deficient NCI-H226 tumors in mice in a dose-dependent manner. VT103 showed excellent orally bioavailability and long half-lives, which inhibits tumor growth and also lead to shrinkage of established tumors in preclinical models of human mesothelioma CDX models deficient in functional Merlin.
信号通路 Wnt/Stem Cell 

结构式

本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
全国免费电话：400-099-8200
在线客服:
技术支持:
orders@biochempartner.com
瀚香官网:
www.biochempartner.com
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！