VT-103 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP45566CAS号：2290608-13-6纯度：98%

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CAS号	2290608-13-6	货号	BCP45566
中文名	VT-103
英文名	VT-103
中文别名
英文别名	VT 103; VT103;
SMILES	CNS(=O)(=O)C1=CC(=C(C=C1)NC2=CC=C(C=C2)C(F)(F)F)C3=CN(C=N3)C
化学名称
分子式	C18H17F3N4O2S	分子量	410.41
纯度	98%	配送	惯例下常温包邮
产品描述	VT-103 is a potent and selective TEAD Auto-palmitoylation inhibitor that Inhibits Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT103 is a TEAD1-selective inhibitor. VT103 is an analog of VT101, which has 238 improved potency and good oral pharmacokinetics in mice. VT103 selectively inhibited endogenous TEAD1 palmitoylation in cells. VT103 significantly downregulated the expression of the Hippo pathway target genes, CTGF and CYR61, in the NF2-deficient NCI-H226 tumors in mice in a dose-dependent manner. VT103 showed excellent orally bioavailability and long half-lives, which inhibits tumor growth and also lead to shrinkage of established tumors in preclinical models of human mesothelioma CDX models deficient in functional Merlin.