BLU-945
| CAS No. | 2660250-10-0 | Cat. No. | BCP45854 |
| Name | BLU-945 | ||
| Synonyms | BLU945;BLU 945; | ||
| Formula | C28H37FN6O3S | M. Wt | 556.7 |
| Description | BLU-945 is a potent, selective, and orally available EGFR inhibitor that shows robust anti-tumor activity in osimertinib-resistant EGFR xenograft models.BLU-945 inhibits EGFRex19del/T790M/C797S, EGFRL858R/T790M/C797S, EGFRex19del/T790M, and EGFRL858R/T790M mutants with sub-nanomolar IC50 values in an enzyme assay with a >1000-fold window over EGFRWT enzyme activity. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| Targets | EGFR | ||
Structure
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