BLU-945 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2660250-10-0 | Cat. No. | BCP45854 |
| Name | BLU-945 | ||
| Synonyms | BLU945;BLU 945; | ||
| SMILES | CC1C(CN1C2=C3C=NC(=CC3=C(C=C2)C(C)C)NC4=NC(=NC=C4)N5CCC(C(C5)F)OC)CS(=O)(=O)C | ||
| Chemical Name | |||
| Formula | C28H37FN6O3S | M. Wt | 556.7 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BLU-945 is a potent, selective, and orally available EGFR inhibitor that shows robust anti-tumor activity in osimertinib-resistant EGFR xenograft models.BLU-945 inhibits EGFRex19del/T790M/C797S, EGFRL858R/T790M/C797S, EGFRex19del/T790M, and EGFRL858R/T790M mutants with sub-nanomolar IC50 values in an enzyme assay with a >1000-fold window over EGFRWT enzyme activity. | ||
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