Ifebemtinib
| CAS号 | 1227948-82-4 | 货号 | BCP45896 |
| 中文名 | Ifebemtinib | ||
| 英文名 | Ifebemtinib | ||
| 中文别名 | |||
| 英文别名 | BI853520;IN10018;BI-853520;IN-10018;BI8 53520;IN 10018; | ||
| 分子式 | C28H28F4N6O4 | 分子量 | 588.55 |
| 生物活性 | Protein Tyrosine Kinase 2 Inhibitor IN10018 is an orally bioavailable inhibitor of the non-receptor, cytoplasmic tyrosine kinase protein tyrosine kinase 2 (focal adhesion kinase 1; FAK1; FAK: PTK2) with potential antineoplastic activity. Upon oral administration, IN10018 targets and inhibits, in an adenosine triphosphate (ATP)-competitive manner, PTK2. This prevents PTK2-mediated downstream signaling and inhibits migration, proliferation, invasion, and survival in PTK2-overexpressing tumor cells. The cytoplasmic tyrosine kinase PTK2, a signal transducer for integrins overexpressed in various tumor cell types, is involved in tumor cell invasion, migration and proliferation. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | FAK | ||
结构式
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