SBI-425
| CAS No. | 1451272-71-1 | Cat. No. | BCP45955 |
| Name | SBI-425 | ||
| Synonyms | SBI425;SBI 425; | ||
| Formula | C13H12ClN3O4S | M. Wt | 341.77 |
| Description | SBI-425 is a potent, selective and oral bioavailable inhibitor of tissue-nonspecific alkaline phosphatase (TNAP) with an IC50 value of 0.016 μM. SBI-425 robustly inhibits TNAP in vivo after oral dosing. Furthermore, SBI-425 demonstrated activity in blocking calcification in patient derived fibroblasts as well as in rodent models of GACI and PXE. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Phosphatase | ||
Structure
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