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CAS No. | 1451272-71-1 | Cat. No. | BCP45955 |
Name | SBI-425 | ||
Synonyms | SBI425;SBI 425; | ||
SMILES | COC1=C(C=C(C=C1)Cl)S(=O)(=O)NC2=CN=CC(=C2)C(=O)N | ||
Chemical Name | |||
Formula | C13H12ClN3O4S | M. Wt | 341.77 |
Purity | 98% | Storage | Store at 4-8°C |
Description | SBI-425 is a potent, selective and oral bioavailable inhibitor of tissue-nonspecific alkaline phosphatase (TNAP) with an IC50 value of 0.016 μM. SBI-425 robustly inhibits TNAP in vivo after oral dosing. Furthermore, SBI-425 demonstrated activity in blocking calcification in patient derived fibroblasts as well as in rodent models of GACI and PXE. |
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