Chk2 Inhibitor
| CAS No. | 724708-21-8 | Cat. No. | BCP46034 |
| Name | Chk2 Inhibitor | ||
| Synonyms | Hymenialdisine Analogue 1;CHK2;SC-203885; SC 203885; SC203885; | ||
| Formula | C15H13N5O2 | M. Wt | 295.3 |
| Description | Chk2 inhibitor is an inhibitor of checkpoint kinase 2 (Chk2; IC50 = 13.5 nM). Chk2 inhibitor enhances survival of 184B5, but not MDA-MB-231, cells following ionizing radiation and inhibits cell cycle arrest at the G2 stage induced by ionizing radiation in 184B5 cells. It also inhibits the production of IL-2 in Jurkat cells, the production of TNF-α in LPS-stimulated THP-1 cells and the growth of CEM leukemia T cells. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Checkpoint | ||
Structure
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