Chk2 Inhibitor New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP46034CAS No. ：724708-21-8Purity：98%

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Chemical Properties&Biological Activity

CAS No.	724708-21-8	Cat. No.	BCP46034
Name	Chk2 Inhibitor
Synonyms	Hymenialdisine Analogue 1;CHK2;SC-203885; SC 203885; SC203885;
SMILES	C1CNC(=O)C2=NC3=CC=CC=C3C2=C1C4=C(N=C(N4)N)O
Chemical Name
Formula	C15H13N5O2	M. Wt	295.3
Purity	98%	Storage	Store at 4-8°C
Description	Chk2 inhibitor is an inhibitor of checkpoint kinase 2 (Chk2; IC50 = 13.5 nM). Chk2 inhibitor enhances survival of 184B5, but not MDA-MB-231, cells following ionizing radiation and inhibits cell cycle arrest at the G2 stage induced by ionizing radiation in 184B5 cells. It also inhibits the production of IL-2 in Jurkat cells, the production of TNF-α in LPS-stimulated THP-1 cells and the growth of CEM leukemia T cells.

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