KGP94
| CAS No. | 1131456-28-4 | Cat. No. | BCP46515 |
| Name | KGP94 | ||
| Synonyms | KGP 94; KGP-94; | ||
| Formula | C14H12BrN3OS | M. Wt | 350.23 |
| Description | KGP94 is a reversible, time-dependent and competitive inhibitor of human cathepsin L. KGP94 inhibits the activity of cathepsin L toward human type I collagen. KGP94 significantly impedes both migration and invasion of MDA-MB-231 human breast cancer cells. Molecular modeling places the thiocarbonyl of KGP94 in proximity to the active site Cys25. Significant growth retardation of C3H mouse mammary carcinomas is achieved with KGP94 treatment. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Cathepsin | ||
Structure
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