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KGP94 Chemical Structure

KGP94

Data Sheet For research use only. Not for human use.
Cat. No. :BCP46515CAS No. :1131456-28-4Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1131456-28-4 Cat. No. BCP46515
Name KGP94
Synonyms KGP 94; KGP-94;
SMILES C1=CC(=CC(=C1)O)C(=NNC(=S)N)C2=CC(=CC=C2)Br
Chemical Name
Formula C14H12BrN3OS M. Wt 350.23
Purity 98% Storage Store at 4-8°C
Description KGP94 is a reversible, time-dependent and competitive inhibitor of human cathepsin L. KGP94 inhibits the activity of cathepsin L toward human type I collagen. KGP94 significantly impedes both migration and invasion of MDA-MB-231 human breast cancer cells. Molecular modeling places the thiocarbonyl of KGP94 in proximity to the active site Cys25. Significant growth retardation of C3H mouse mammary carcinomas is achieved with KGP94 treatment.
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