AP1189
| CAS No. | 959850-73-8 | Cat. No. | BCP46590 |
| Name | AP1189 | ||
| Synonyms | AP-1189;AP 1189; | ||
| Formula | C14H14N6O2 | M. Wt | 298.31 |
| Description | AP1189 is a biased agonist at receptors MC1 and MC3. AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes. In vivo, oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ∼3-fold. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Melanocortin Receptor | ||
Structure
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