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AP1189 Chemical Structure

AP1189

Data Sheet For research use only. Not for human use.
Cat. No. :BCP46590CAS No. :959850-73-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 959850-73-8 Cat. No. BCP46590
Name AP1189
Synonyms AP-1189;AP 1189;
SMILES C1=CC=C(C(=C1)N2C=CC=C2C=CC=NN=C(N)N)[N+](=O)[O-]
Chemical Name
Formula C14H14N6O2 M. Wt 298.31
Purity 98% Storage Store at 4-8°C
Description AP1189 is a biased agonist at receptors MC1 and MC3. AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes. In vivo, oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ∼3-fold.
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