雷罗他非
| CAS号 | 1008510-37-9 | 货号 | BCP46999 |
| 中文名 | 雷罗他非 | ||
| 英文名 | Razuprotafib | ||
| 中文别名 | |||
| 英文别名 | AKB-9778; AKB 9778; AKB9778; | ||
| 分子式 | C26H26N4O6S3 | 分子量 | 586.7 |
| 生物活性 | Razuprotafib is a small molecule inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP), with potential vasculature stabilizing activity. Upon administration, razuprotafib targets, binds to and inhibits VE-PTP, which is a negative regulator of the endothelial cell (EC)-specific receptor tyrosine kinase (RTK) Tie2. This restores Tie2 activation, which may improve endothelial function and stabilize blood vessels. VE-PTP is upregulated in stressed endothelium associated with a variety of diseases. Tie2 plays an important role in endothelial function and vascular stability. A decrease in Tie2 activation leads to vascular leakage and inflammation. | ||
| 上下游产品 | 1809275-69-1（Razuprotafib sodium） | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Phosphatase | ||
结构式
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