(2S)-2-hydroxypentanedioic acid
| CAS No. | 13095-48-2 | Cat. No. | BCP47205 |
| Name | (2S)-2-hydroxypentanedioic acid | ||
| Synonyms | L-2-hydroxyglutarate; | ||
| Formula | C5H8O5 | M. Wt | 148.11 |
| Description | (2S)-2-hydroxypentanedioic acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively. | ||
| Pathways | Epigenetics | ||
| Targets | Histone Demethylase | ||
Structure
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