RMC-5552
CAS No. | 2382768-62-7 | Cat. No. | BCP48880 |
Name | RMC-5552 | ||
Synonyms | RMC5552;RMC 5552; | ||
Formula | C93H136N10O24 | M. Wt | 1778.16 |
Description | RMC-5552 is a potent and selective mTORC1 inhibitor. RMC-5552 inhibits phosphorylation of mTORC1 pS6K and p4EBP1 with IC50s of 0.14 nM and 0.48 nM, respectively. RMC-5552 shows much lower pAKT inhibition (IC50 of 19 nM), resulting in mTORC1/mTORC2 selectivity approaching 40-fold. RMC-5552 has anti-cancer activity. | ||
Pathways | PI3K/Akt/mTOR | ||
Targets | mTOR |
Structure
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