RMC-5552

  • Chemical Properties
CAS No. 2382768-62-7 Cat. No. BCP48880
Name RMC-5552
Synonyms RMC5552;RMC 5552;
Formula C93H136N10O24 M. Wt 1778.16
  • Biological Activity
Description RMC-5552 is a potent and selective mTORC1 inhibitor. RMC-5552 inhibits phosphorylation of mTORC1 pS6K and p4EBP1 with IC50s of 0.14 nM and 0.48 nM, respectively. RMC-5552 shows much lower pAKT inhibition (IC50 of 19 nM), resulting in mTORC1/mTORC2 selectivity approaching 40-fold. RMC-5552 has anti-cancer activity.
Pathways PI3K/Akt/mTOR 
Targets mTOR 

Structure

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