Pactimibe
| CAS No. | 189198-30-9 | Cat. No. | BCP48994 |
| Name | Pactimibe | ||
| Synonyms | CS-505; CS505; CS 505; | ||
| Formula | C25H40N2O3 | M. Wt | 416.6 |
| Description | Pactimibe is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively. Pactimibe noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. Moreover, Pactimibe obviously inhibits cholesteryl ester formation with an IC50 of 6.7 μM. Pactimibe possesses anti-atherosclerotic potential with lowering plasma cholesterol activity. | ||
| Related Products | 608510-47-0（Pactimibe sulfate） | ||
| Pathways | Protease/Metabolic Enzyme | ||
Structure
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