Pactimibe sulfate New
Data Sheet
For research use only. Not for human use.
| Size | Price | Stock | Quotation Inquiry |
|---|---|---|---|
| 10.00 mg | Get quote | In-stock | Quotation Inquiry |
| 25.00 mg | Get quote | In-stock | Quotation Inquiry |
| 50.00 mg | Get quote | In-stock | Quotation Inquiry |
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| CAS No. | 608510-47-0 | Cat. No. | BCP45168 |
| Related Products | 189198-30-9（Pactimibe） | ||
| Name | Pactimibe sulfate | ||
| Synonyms | CS-505 sulfate; CS505 sulfate; CS 505 sulfate; | ||
| SMILES | CCCCCCCCN1CCC2=C(C(=C(C(=C21)NC(=O)C(C)(C)C)C)CC(=O)O)C.CCCCCCCCN1CCC2=C(C(=C(C(=C21)NC(=O)C(C)(C)C)C)CC(=O)O)C.OS(=O)(=O)O | ||
| Chemical Name | |||
| Formula | C50H82N4O10S | M. Wt | 931.28 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Pactimibe, also known as CS-505, is a ACAT inhibitor. Pactimibe stabilizes atherosclerotic plaque through macrophage acyl-CoA:cholesterol acyltransferase inhibition in WHHL rabbits. Pactimibe reduces and stabilizes atherosclerotic lesions by cholesterol-lowering and direct effects in apolipoprotein E-deficient mice. Pactimibe inhibits cholesterol absorption from the intestine, reduces cholesteryl ester formation in the liver, and enhances its elimination from the body. The Triton WR-1339 experiment showed that pactimibe inhibited secretion of very low density lipoprotein cholesterol from the liver. These results suggest that pactimibe is likely to have multiple mechanisms of action responsible for its effectiveness in reducing serum cholesterol. | ||
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