Lutetium Lu177 edotreotide

CAS No.	321835-55-6	Cat. No.	BCP49208
Name	Lutetium Lu177 edotreotide
Synonyms	Lu-DOTA-TOC;Dotatoc Lu-177;Edotreotide lutetium Lu-177;
Formula	C65H89LuN14O18S2	M. Wt	1596.61

Description	Lutetium Lu 177-Edotreotide is a radioconjugate consisting of the somatostatin analogue edotreotide labeled with lutetium Lu 177 with potential antineoplastic activities. Lutetium Lu 177-edotreotide binds to somatostatin receptors (SSTRs), with high affinity to type 2 SSTR, present on the cell membranes of many types of neuroendocrine tumor cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to SSTR-positive cells. Edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of the somatostatin analogue octreotide (Tyr3-octreotide or TOC) and chelated by the bifunctional, macrocyclic chelating agent dodecanetetraacetic acid (DOTA).
Pathways	GPCR/G Protein
Targets	Somatostatin Receptor

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