Lutetium Lu177 edotreotide New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 321835-55-6 | Cat. No. | BCP49208 |
| Name | Lutetium Lu177 edotreotide | ||
| Synonyms | Lu-DOTA-TOC;Dotatoc Lu-177;Edotreotide lutetium Lu-177; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C65H89LuN14O18S2 | M. Wt | 1596.61 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Lutetium Lu 177-Edotreotide is a radioconjugate consisting of the somatostatin analogue edotreotide labeled with lutetium Lu 177 with potential antineoplastic activities. Lutetium Lu 177-edotreotide binds to somatostatin receptors (SSTRs), with high affinity to type 2 SSTR, present on the cell membranes of many types of neuroendocrine tumor cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to SSTR-positive cells. Edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of the somatostatin analogue octreotide (Tyr3-octreotide or TOC) and chelated by the bifunctional, macrocyclic chelating agent dodecanetetraacetic acid (DOTA). | ||
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