GNE-617 hydrochloride
| CAS No. | 2070014-99-0 | Cat. No. | BCP49280 |
| Name | GNE-617 hydrochloride | ||
| Synonyms | GNE 617 hydrochloride;GNE617 hydrochloride; | ||
| Formula | C21H16ClF2N3O3S | M. Wt | 463.88 |
| Description | GNE-617 hydrochloride is a potent and competitive inhibitor of nicotinamide phosphoribosyltransferase (IC50: 5nM). GNE-617 hydrochloride reduces the NAD levels in a > 95% reduction in both NAPRT1-deficient and NAPRT1-proficient cell lines and exerts (EC50: 0.54nM to 4.69nM). | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Nampt | ||
Structure
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