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GNE-617 hydrochloride Chemical Structure

GNE-617 hydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP49280CAS No. :2070014-99-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2070014-99-0 Cat. No. BCP49280
Name GNE-617 hydrochloride
Synonyms GNE 617 hydrochloride;GNE617 hydrochloride;
SMILES C1=CC(=CC=C1CNC(=O)C2=CN3C=CN=C3C=C2)S(=O)(=O)C4=CC(=CC(=C4)F)F.Cl
Chemical Name
Formula C21H16ClF2N3O3S M. Wt 463.88
Purity 98% Storage Store at 4-8°C
Description GNE-617 hydrochloride is a potent and competitive inhibitor of nicotinamide phosphoribosyltransferase (IC50: 5nM). GNE-617 hydrochloride reduces the NAD levels in a > 95% reduction in both NAPRT1-deficient and NAPRT1-proficient cell lines and exerts (EC50: 0.54nM to 4.69nM).
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