Brigimadlin
| CAS No. | 2095116-40-6 | Cat. No. | BCP49630 |
| Name | Brigimadlin | ||
| Synonyms | BI 907828;BI 907828;BI 907828; | ||
| Formula | C31H25Cl2FN4O3 | M. Wt | 591.46 |
| Description | Brigimadlin is an orally available inhibitor of murine double minute 2 (MDM2), with potential antineoplastic activity. Upon oral administration, brigimadlin binds to MDM2 protein and prevents its binding to the transcriptional activation domain of the tumor suppressor protein p53. By preventing MDM2-p53 interaction, the transcriptional activity of p53 is restored. This leads to p53-mediated induction of tumor cell apoptosis. Compared to currently available MDM2 inhibitors, the pharmacokinetic properties of BI 907828 allow for more optimal dosing and dose schedules that may reduce myelosuppression, an on-target, dose-limiting toxicity for this class of inhibitors. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | Mdm2 | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.