Brigimadlin New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP49630CAS No. ：2095116-40-6Purity：98%

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CAS No.	2095116-40-6	Cat. No.	BCP49630
Name	Brigimadlin
Synonyms	BI 907828;BI 907828;BI 907828;
SMILES	CC1=C(C=CC2=C3CC4C(N3N=C12)C(C5(N4CC6CC6)C7=C(C=C(C=C7)Cl)NC5=O)C8=C(C(=CC=C8)Cl)F)C(=O)O
Chemical Name
Formula	C31H25Cl2FN4O3	M. Wt	591.46
Purity	98%	Storage	Store at 4-8°C
Description	Brigimadlin is an orally available inhibitor of murine double minute 2 (MDM2), with potential antineoplastic activity. Upon oral administration, brigimadlin binds to MDM2 protein and prevents its binding to the transcriptional activation domain of the tumor suppressor protein p53. By preventing MDM2-p53 interaction, the transcriptional activity of p53 is restored. This leads to p53-mediated induction of tumor cell apoptosis. Compared to currently available MDM2 inhibitors, the pharmacokinetic properties of BI 907828 allow for more optimal dosing and dose schedules that may reduce myelosuppression, an on-target, dose-limiting toxicity for this class of inhibitors.