布里吉马德林
| CAS号 | 2095116-40-6 | 货号 | BCP49630 |
| 中文名 | 布里吉马德林 | ||
| 英文名 | Brigimadlin | ||
| 中文别名 | |||
| 英文别名 | BI 907828;BI 907828;BI 907828; | ||
| 分子式 | C31H25Cl2FN4O3 | 分子量 | 591.46 |
| 生物活性 | Brigimadlin is an orally available inhibitor of murine double minute 2 (MDM2), with potential antineoplastic activity. Upon oral administration, brigimadlin binds to MDM2 protein and prevents its binding to the transcriptional activation domain of the tumor suppressor protein p53. By preventing MDM2-p53 interaction, the transcriptional activity of p53 is restored. This leads to p53-mediated induction of tumor cell apoptosis. Compared to currently available MDM2 inhibitors, the pharmacokinetic properties of BI 907828 allow for more optimal dosing and dose schedules that may reduce myelosuppression, an on-target, dose-limiting toxicity for this class of inhibitors. | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | Mdm2 | ||
结构式
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