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Brigimadlin 结构式

布里吉马德林

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货号 :BCP49630CAS号 :2095116-40-6纯度:98%
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  • 基本信息与产品描述
CAS号 2095116-40-6 货号 BCP49630
中文名 布里吉马德林
英文名 Brigimadlin
中文别名
英文别名 BI 907828;BI 907828;BI 907828;
SMILES CC1=C(C=CC2=C3CC4C(N3N=C12)C(C5(N4CC6CC6)C7=C(C=C(C=C7)Cl)NC5=O)C8=C(C(=CC=C8)Cl)F)C(=O)O
化学名称
分子式 C31H25Cl2FN4O3 分子量 591.46
纯度 98% 配送 惯例下常温包邮
产品描述 Brigimadlin is an orally available inhibitor of murine double minute 2 (MDM2), with potential antineoplastic activity. Upon oral administration, brigimadlin binds to MDM2 protein and prevents its binding to the transcriptional activation domain of the tumor suppressor protein p53. By preventing MDM2-p53 interaction, the transcriptional activity of p53 is restored. This leads to p53-mediated induction of tumor cell apoptosis. Compared to currently available MDM2 inhibitors, the pharmacokinetic properties of BI 907828 allow for more optimal dosing and dose schedules that may reduce myelosuppression, an on-target, dose-limiting toxicity for this class of inhibitors.
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