RAS-IN-2
| CAS No. | 2765081-21-6 | Cat. No. | BCP49648 |
| Name | RAS-IN-2 | ||
| Synonyms | RMC6236;RMC 6236;RMC-6236;RAS Inhibitor A122; | ||
| Formula | C44H58N8O5S | M. Wt | 811.06 |
| Description | RAS-IN-2 (RMC-6236) is an orally bioavailable pan-RAS inhibitor. RMC-6236 binds to an intracellular chaperone protein, cyclophilin A (CypA). The resulting inhibitory binary complex binds to active, GTP-bound RAS to form a tri-complex. This tri-complex inhibits RAS-dependent signaling and inhibits the proliferation of tumor cells in which RAS is overexpressed and/or mutated. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Ras/Rho | ||
Structure
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