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RAS-IN-2 Chemical Structure

RAS-IN-2

Data Sheet For research use only. Not for human use.
Cat. No. :BCP49648CAS No. :2765081-21-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2765081-21-6 Cat. No. BCP49648
Name RAS-IN-2
Synonyms RMC6236;RMC 6236;RMC-6236;RAS Inhibitor A122;
SMILES CCN1C2=C3C=C(C=C2)C4=CSC(=N4)CC(C(=O)N5CCCC(N5)C(=O)OCC(CC3=C1C6=C(N=CC(=C6)N7CCN(CC7)C)C(C)OC)(C)C)NC(=O)C8CC8C
Chemical Name
Formula C44H58N8O5S M. Wt 811.06
Purity 98% Storage Store at 4-8°C
Description RAS-IN-2 (RMC-6236) is an orally bioavailable pan-RAS inhibitor. RMC-6236 binds to an intracellular chaperone protein, cyclophilin A (CypA). The resulting inhibitory binary complex binds to active, GTP-bound RAS to form a tri-complex. This tri-complex inhibits RAS-dependent signaling and inhibits the proliferation of tumor cells in which RAS is overexpressed and/or mutated.
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