MTX115325
| CAS No. | 2750895-97-5 | Cat. No. | BCP49673 |
| Name | MTX115325 | ||
| Synonyms | MTX-115325;MTX 115325; | ||
| Formula | C18H16N6O2 | M. Wt | 348.36 |
| Description | MTX115325 is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC50=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine. | ||
| Pathways | Others Pathway | ||
| Targets | Autophagy | ||
Structure
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