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CAS No. | 2750895-97-5 | Cat. No. | BCP49673 |
Name | MTX115325 | ||
Synonyms | MTX-115325;MTX 115325; | ||
SMILES | |||
Chemical Name | |||
Formula | C18H16N6O2 | M. Wt | 348.36 |
Purity | 98% | Storage | Store at 4-8°C |
Description | MTX115325 is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC50=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine. |
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