甘氨鹅脱氧胆酸
| CAS号 | 640-79-9 | 货号 | BCP49686 |
| 中文名 | 甘氨鹅脱氧胆酸 | ||
| 英文名 | Glycochenodeoxycholic acid | ||
| 中文别名 | 甘鹅去氧胆酸;甘氨鹅去氧胆酸; | ||
| 英文别名 | GCDC;Glycochenodeoxycholate;Chenodeoxycholylglycine;Glycine chenodeoxycholate; | ||
| 分子式 | C26H43NO5 | 分子量 | 449.62 |
| 生物活性 | Glycochenodeoxycholic acid is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC). | ||
| 信号通路 | Protease/Metabolic Enzyme Apoptosis Pathway | ||
| 靶 点 | Caspase | ||
结构式
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