喹吖因二盐酸
| CAS号 | 69-05-6 | 货号 | BCP49707 |
| 中文名 | 喹吖因二盐酸 | ||
| 英文名 | Quinacrine dihydrochloride | ||
| 中文别名 | 二盐酸奎吖因 ;阿的平 二盐酸盐;二盐酸阿的平; | ||
| 英文别名 | Quinacrine 2HCl;Mepacrine dihydrochloride; SN-390 dihydrochloride; | ||
| 分子式 | C23H32Cl3N3O | 分子量 | 472.88 |
| 生物活性 | Quinacrine Hydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB), which may result in the induction of tumor suppressor p53 transcription, the restoration of p53-dependent apoptotic pathways, and tumor cell apoptosis. Continuous NF-kappaB signaling, present in many tumors and in chronic inflammatory processes, promotes the expression of antiapoptotic proteins and cytokines while downregulating the expression of proapoptotic proteins, such as p53. | ||
| 信号通路 | Microbiology/Virology | ||
| 靶 点 | Antiparasitics | ||
结构式
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