MRT-2359
| CAS No. | 2803881-11-8 | Cat. No. | BCP49710 |
| Name | MRT-2359 | ||
| Synonyms | MRT2359;MRT 2359; | ||
| Formula | C22H17F4N3O6 | M. Wt | 495.38 |
| Description | MRT-2359 is a potent, orally active and selective GSPT1 depressant (IC50: >30 nM and <300 nM) that specifically induces apoptosis dependent on protein translation. MRT-2359 exhibits significant and preferred anti-proliferative activity in a variety of cancer cell lines, especially MYC-driven cell lines, such as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with high expression of N-Myc or L-Myc. MRT-2359 inhibits the growth of drug-resistant NSCLC and SCLC cells, making it suitable for cancer research. | ||
| Pathways | Apoptosis Pathway | ||
Structure
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