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CAS No. | 2803881-11-8 | Cat. No. | BCP49710 |
Name | MRT-2359 | ||
Synonyms | MRT2359;MRT 2359; | ||
SMILES | C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=C(C=C3)COC(=O)NC4=C(C=CC(=C4)OC(F)(F)F)F | ||
Chemical Name | |||
Formula | C22H17F4N3O6 | M. Wt | 495.38 |
Purity | 98% | Storage | Store at 4-8°C |
Description | MRT-2359 is a potent, orally active and selective GSPT1 depressant (IC50: >30 nM and <300 nM) that specifically induces apoptosis dependent on protein translation. MRT-2359 exhibits significant and preferred anti-proliferative activity in a variety of cancer cell lines, especially MYC-driven cell lines, such as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with high expression of N-Myc or L-Myc. MRT-2359 inhibits the growth of drug-resistant NSCLC and SCLC cells, making it suitable for cancer research. |
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