Lovastatin

CAS No.	75330-75-5	Cat. No.	BCP20921
Name	Lovastatin
Synonyms	Mevinolin; Mevacor; Monacolin K; Altoprev; MK 803; MK-803; MK803; Monacolin K;
Formula	C24H36O5	M. Wt	404.54

Description	Lovastatin inhibits HMGCR, blocking the enzyme-catalyzed transformation of 3-hydroxy-3-methylglutaryl CoA into mevalonate. Lovastatin is a statin natural product isolated from numerous sources including the Pleurotus ostreatus oyster mushroom, demonstrating hypocholesterolemic and antiproliferative properties. The biosynthesis of cholesterol requires mevalonate as a building block and elimination of mevalonate generation subsequently interrupts cholesterol synthesis, leading to a reduction of circulating low-density lipoproteins. Lovastatin demonstrates arrest of the cell cycle at the G1 phase in bladder carcinoma T24 cells.
Pathways	Protease/Metabolic Enzyme
Targets	HMGCR

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