Lovastatin
Data Sheet
For research use only. Not for human use.
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| CAS No. | 75330-75-5 | Cat. No. | BCP20921 |
| Name | Lovastatin | ||
| Synonyms | Mevinolin; Mevacor; Monacolin K; Altoprev; MK 803; MK-803; MK803; Monacolin K; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H36O5 | M. Wt | 404.54 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Lovastatin inhibits HMGCR, blocking the enzyme-catalyzed transformation of 3-hydroxy-3-methylglutaryl CoA into mevalonate. Lovastatin is a statin natural product isolated from numerous sources including the Pleurotus ostreatus oyster mushroom, demonstrating hypocholesterolemic and antiproliferative properties. The biosynthesis of cholesterol requires mevalonate as a building block and elimination of mevalonate generation subsequently interrupts cholesterol synthesis, leading to a reduction of circulating low-density lipoproteins. Lovastatin demonstrates arrest of the cell cycle at the G1 phase in bladder carcinoma T24 cells. | ||
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